Silymarin from milk thistle research, dosage, benefit and side effects, use for liver health February 1 2017 by Ray Sahelian, M.D. Silymarin. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Joshua P. Gray, Sidhartha D. Ray, in Side Effects of Drugs Annual, 2016. Silymarin, also called Flavobion or Legalon, is a powerful antioxidant that seems to benefit your liver the most. Silymarin, found within the seeds, contains active agents that become concentrated in milk thistle extract . According to clinical studies, Iberogast mildly … This is not a complete list of side effects and others may occur. Find treatment reviews for Silymarin from other patients. Silymarin, CAS# 22888-70-6, is a Plant extracts manufactured through plant extraction, available as Yellow to Yellowish-Brown Powder. The abuse of tadalafil, which is a worldwide problem, is associated with many side effects. These include: Some of the side-effects may be rare but serious. Studies have confirmed that the active components in milk thistle have hepatoprotective effects—that is, they can help protect the … About 50 percent to 70 percent of the silymarin molecules present within milk thistle are the type called silybin, also known as silibinin. Occasionally, people report various digestive side effects. However, other side effects may include headaches, joint pain, or sexual dysfunction. The purpose of this study was to investigate the efficacy of silymarin gel in prevention of radiodermatitis in patients with breast cancer. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. by Shawn 2015-02-02. Select the most affordable brand or generic drug. This is not a comprehensive list. Silymarin side effects Abdominal bloating, diarrhea, flatulence, loss of appetite, nausea and stomach upset. Milk thistle is commonly used as a home remedy to treat liver problems, often under the presumption that it will "detoxify" the liver. Milk Thistle Side Effects. Since it’s a toxin obstruction agent, silymarin also prevents the formation of cancerous cells in the body. Silymarin, a flavonoid extracted from the Silybum marianum, exhibits antioxidant and anti-inflammatory activities. Remember: Milk thistle extracts should be high in silymarin (60 – 80%) and a large part of this silymarin complex should be silybin (at least 20% but aim for those with 50 – 70%)! Silymarin and its components show great therapeutic promise, and are the subjects of ongoing research and clinical trials. According to studies, milk thistle contains essential phytochemicals that effectively inhibit the harmful effects of UV light on the skin. Milk thistle is an herb with a long history of use for indigestion, liver and gallbladder problems. Milk thistle extract is LIKELY SAFE when taken by mouth for most adults. 4. Silymarin is widely used as nutrition supplements. nausea, loss of appetite. One of these is called silybin, which makes up 50% – 70% of silymarin and is the most biologically active and beneficial constituent of silymarin. Silymarin storage conditions Store it at room temperature. Radiation-induced dermatitis is one of the most common side effects of radiotherapy. When reported, side effects for milk thistle are generally gut disturbances like diarrhea, nausea or bloating. The Latin name for milk thistle is Silybum marianum. It is used as an herbal remedy for liver treatment. Common side effects may include: indigestion, bloating, gas, stomach pain; diarrhea; or. Active ingredients: Silymarin. Silymarin is an extract from Silybum marianum (milk thistle) which contains various flavonolignans (including silybin). Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated … Being a product with no proven toxicity and side effects, considered to be safe for therapeutic use, silymarin was studied in different pathological conditions such as Alzheimer's disease, Parkinson's disease, sepsis, burns, osteoporosis, diabetes, hypercholesterolemia [].In human medicine, silymarin is a promising drug used in liver diseases, with proved benefits even in cholestasis []. It is possible to be allergic to milk thistle as well and have a serious allergic reaction. Properties of Silymarin. The seeds contain silymarin, a group of compounds said to have antioxidant and anti-inflammatory effects. Milk thistle contains a substance known as silymarin, which is found in the seeds. Side effects are common for any medication, including OTC and prescription drugs. However, remember to immediately consult your doctor if you experience any side effect that persists or causes any discomfort. Milk thistle is an herbal remedy that has been used for around 2000 years in the treatment of various health concerns. Other less common side effects are nausea, diarrhea, indigestion, intestinal gas, bloating, fullness or pain, and loss of appetite.. The following is a list of possible side-effects that may occur in medicines that contain Silymarin. When dealing with alternative medicine, it is sensible to research about the side effects before trying one. Milk thistle sometimes causes a laxative effect. Milk Thistle & Silymarin Dosage + Side Effects & Interactions; Takeaway. Taken in recommended dosages, milk thistle extract is a safe health supplement. The side effects that are associated with using this medication are rare. Learn from their experiences about effectiveness, side effects and cost ... amount on an average the dosage should be approximately between 280-800 mg of silymarin and the concentration of silymarin in milk thistle is between 70-80%. After reading about many benefits of milk thistle, you could be curious whether it has any side effect. Silymarin Side Effects. At doses greater than 1.5 grams per day the increased bile flow side effect may cause diarrhea. There is strong preclinical evidence for silymarin’s hepatoprotective and anticarcinogenic effects, including inhibition of cancer cell growth in human prostate, skin, breast, and cervical cells. ere are some side effects of milk thistle that can produce some life threatening. Though generally considered safe, it is known to cause adverse effects in … There isn't enough reliable information available to know if milk thistle is safe to apply to the skin or inject into the body. Silymarin is made up of three other compounds. Milk thistle is a herb which belongs to the ragweed and daisy family. Phytogenic treatments for hyperglycemia and its side effects in Sprague- Dawley male albino rats Of those currently taking CMs, 195/269 (72%) were ingesting silymarin (58). Silymarin is a specific milk thistle extract mixture. Further information Legalon® may cause these side effects, such as a mild laxative action has been observed in occasional instances. These side-effects are possible, but do not always occur. Silymarin plays a role in cell renewal and flushing out toxins from the body. pregnancy, upcoming surgery, etc. The side effects of milk thistle and milk thistle extract are pretty limited (as far as is known), with the only effects being the occasional report of nausea or diarrhea. Side effects What side effects can occur from Legalon® (Silymarin)? Side effects: If the patient is allergic to milk thistle plant then they should avoid silymarin. The active ingredient of milk thistle is a flavinoid called silymarin that is found in the seeds. Call your doctor for medical advice about side effects. Even in case of allergies with members of the Asteraceae or Compositae family, Silybum marianum, ragweed, daisies and sunflower silymarin should be avoided. It is widely accepted as … ), allergies, pre-existing diseases, and current health conditions (e.g. Phosphatidyl choline is added to some oral preparations of silymarin as it enhances silymarin absorption into the body from the GI tract. Email: inquiry@foodchem.cn. If side effects … ).Some health conditions may make you more susceptible to the side-effects of the drug. Some people are advised to be cautious when taking milk thistle. This is not a complete list of side effects and others may occur. Keep European Milk Thistle (Silymarin-Silibinins-Isosilybin A & B) herbs out of reach of children, Do not exceed recommended dose, If you have a bad reaction or side effects, discontinue use immediately, When using European Milk Thistle (Silymarin-Silibinins … But a recent study suggests that silymarin can also be used to reduce the harmful side effects of chemotherapy. Before using Silymarin Plus Vitamin B Complex Capsule, inform your doctor about your current list of medications, over the counter products (e.g. In clinical trials, milk thistle appears to be well tolerated in recommended doses. vitamins, herbal supplements, etc. Consult your doctor if you observe any of the following side-effects, especially if they do not go away. Some very minor allergic reactions include diarrhea, bloated feeling, skin rash, stomach pain, dizziness and itchiness. Silymarin, the active ingredient in milk thistle (Silybum marianum), is a flavonoid commonly used to treat liver disorders. Silymarin, the active extract from milk thistle, is a complex of several flavonolignans and polyphenols.The most active compound in slymarin is silibinin. Milk Thistle Extract Side Effects. Milk thistle (Silybum marianum) is a medicinal herb native to Southern Europe.This herbal medicine possesses antioxidant and anti-inflammatory properties and has several health benefits. 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